'Sentinel' mutations in standard population sequencing can predict the presence of HIV-1 reverse transcriptase major mutations detectable only by ultra-deep pyrosequencing.

doi:10.1093/jac/dkr354

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Article

'Sentinel' mutations in standard population sequencing can predict the presence of HIV-1 reverse transcriptase major mutations detectable only by ultra-deep pyrosequencing.

The Journal of antimicrobial chemotherapy - 1 Nov 2011

Alteri Claudia, Santoro Maria Mercedes, Abbate Isabella, Rozera Gabriella, Bruselles Alessandro, Bartolini Barbara, Gori Caterina, Forbici Federica, Orchi Nicoletta, Tozzi Valerio, Palamara Guido, Antinori Andrea, Narciso Pasquale, Girardi Enrico, Svicher Valentina, Ceccherini-Silberstein Francesca, Capobianchi Maria Rosaria, Perno Carlo Federico

Abstract excerpt

OBJECTIVES: This proof-of-concept study aimed to identify whether mutations considered not yet relevant for drug resistance (but located at key drug-resistance positions) can act as 'sentinels' of minority resistant variants in HIV-1 drug-naive patients. METHODS: We focused our attention on three reverse transcriptase (RT) mutations (T69S, L210M and K103R) easily detected by standard population sequencing [i.e....

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PMID: 21890537
DOI: 10.1093/jac/dkr354

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