Article
MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation.
Journal of cell science - 15 Jul 2010
Galli Francesco, Rossi Mariangela, D'Alessandra Yuri, De Simone Marco, Lopardo Teresa, Haupt Ygal, Alsheich-Bartok Osnat, Anzi Shira, Shaulian Eitan, Calabrò Viola, La Mantia Girolama, Guerrini Luisa
Abstract excerpt
Tight control of p63 protein levels must be achieved under differentiation or apoptotic conditions. Here, we describe a new regulatory pathway for the DeltaNp63alpha protein. We found that MDM2 binds DeltaNp63alpha in the nucleus promoting its translocation to the cytoplasm. The MDM2 nuclear localization signal is required for DeltaNp63alpha nuclear export and subsequent degradation, whereas the MDM2 ring-finger...
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