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Article

Regulation of MDMX Expression by Mitogenic Signaling

3 Jan 2008

Abstract excerpt

MDMX is an important regulator of p53 transcriptional activity and stress response. MDMX overexpression and gene amplification are implicated in p53 inactivation and tumor development. Unlike MDM2, MDMX is not inducible by p53, and little is known about its regulation at the transcriptional level. We found that MDMX levels in tumor cell lines closely correlate with promoter activity and mRNA level. Activated...

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PMID: 18172009
DOI: 10.1128/mcb.01633-07

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