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Article

E2 Ubiquitin-conjugating Enzyme, UBE2C Gene, Is Reciprocally Regulated by Wild-type and Gain-of-Function Mutant p53.

The Journal of biological chemistry - 1 Jul 2016

Bajaj Swati, Alam Sk Kayum, Roy Kumar Singha, Datta Arindam, Nath Somsubhra, Roychoudhury Susanta

Abstract excerpt

Spindle assembly checkpoint governs proper chromosomal segregation during mitosis to ensure genomic stability. At the cellular level, this event is tightly regulated by UBE2C, an E2 ubiquitin-conjugating enzyme that donates ubiquitin to the anaphase-promoting complex/cyclosome. This, in turn, facilitates anaphase-onset by ubiquitin-mediated degradation of mitotic substrates. UBE2C is an important marker of...

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Identifiers

PMID: 27129209
DOI: 10.1074/jbc.M116.731398
PMCID: PMC4933179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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