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Article

A longevity protein, Lag2, interacts with SCF complex and regulates SCF function.

The EMBO journal - 4 Nov 2009

Liu Yuan, Mimura Satoru, Kishi Tsutomu, Kamura Takumi

Abstract excerpt

SCF-type E3-ubiquitin ligases control numerous cellular processes through the ubiquitin-proteasome pathway. However, the regulation of SCF function remains largely uncharacterized. Here, we report a novel SCF complex-interacting protein, Lag2, in Saccharomyces cerevisiae. Lag2 interacts with the SCF complex under physiological conditions. Lag2 negatively controls the ubiquitylation activities of SCF E3 ligase by...

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Source

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Identifiers

PMID: 19763088
DOI: 10.1038/emboj.2009.268
PMCID: PMC2776101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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