Article
TRIM24-mediated K27-linked ubiquitination of ULK1 alleviates energy stress-induced autophagy and promote prostate cancer growth in the context of SPOP mutation.
Cell death and differentiation - 1 Mar 2026
Chen Shimin, Lin Jichun, Yang Zhan, Wang Yuanjing, Wang Qiang, Wang Dong, Qu Yue, Lin Qian, Liu Jia, Yan Shi, Wang Zixin, Qian Xueyu, Xiao Yutian, Li Xue, Chen Yinuo, Fang Wenshuo, Zhao Jiaojiao, Lu Zhimin, Ren He, Zhu Yasheng, Ma Leina
Abstract excerpt
SPOP, the most frequently mutated gene in prostate cancer, has been implicated in the aberrant activation of stress granules, presenting significant challenges in disease management. However, the mechanistic link between SPOP mutations and cellular energy stress remains inadequately explored. In this study, we demonstrate that ULK1 expression is positively correlated with both loss-of-function mutations in SPOP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.