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Article

A genetic-algorithm approach to simulating human immunodeficiency virus evolution reveals the strong impact of multiply infected cells and recombination.

The Journal of general virology - 1 Nov 2005

Bocharov Gennady, Ford Neville J, Edwards John, Breinig Tanja, Wain-Hobson Simon, Meyerhans Andreas

Abstract excerpt

It has been previously shown that the majority of human immunodeficiency virus type 1 (HIV-1)-infected splenocytes can harbour multiple, divergent proviruses with a copy number ranging from one to eight. This implies that, besides point mutations, recombination should be considered as an important mechanism in the evolution of HIV within an infected host. To explore in detail the possible contributions of...

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Identifiers

PMID: 16227234
DOI: 10.1099/vir.0.81138-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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