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Article

Multiplicity of Human Immunodeficiency Virus Infections in Lymphoid Tissue

27 Jul 2004

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1)-infected splenocytes in humans were recently shown to harbor three to four proviruses per cell on average (A. Jung et al., Nature 418:144, 2002). However, the mechanisms that lead to such extensive multiple infections are not understood. Here, we find by using mathematical analysis that two mechanisms quantitatively capture the distribution of proviral genomes in...

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PMID: 15280505
DOI: 10.1128/jvi.78.16.8942-8945.2004

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