MEK inhibition enhances the antitumor effect of radiation therapy in <i>NF1</i> -deficient glioblastoma

Abstract excerpt

Individuals with neurofibromatosis type 1 (NF-1), an autosomal dominant neurogenetic and tumor predisposition syndrome, are susceptible to developing low-grade glioma (LGG) and, less commonly, high-grade glioma (HGG). These gliomas exhibit loss of the neurofibromin gene ( NF1) , and 10-15% of sporadic HGG have somatic NF1 alterations. Loss of NF1 leads to hyperactive RAS signaling, creating opportunity given the...

Topics

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• Glioma Diagnosis and Treatment
• Immunotherapy
• Melanoma and MAPK Pathways
• Molecular Targeted Therapy
• Neurofibromatosis 1
• Neurofibromatosis and Schwannoma Cases
• Neurofibromin 1
• Signal Transduction

Identifiers and source

Literature Corpus work

a43980b4-8278-5e02-8da2-a0b871277f51

DOI

10.1101/2023.08.04.552061