Article
Using genetic variation to optimize cancer chemotherapy.
Clinical advances in hematology & oncology : H&O - 1 Feb 2003
McLeod Howard L, Papageorgio Chris, Watters James W
Abstract excerpt
The high level of interpatient variation in response to chemotherapy and the lack of objective tools to select chemotherapy regimens for a given tumor type have created a clinical problem. A possible solution may be pharmacogenetics: the study of inherited DNA polymorphisms that influence drug disposition and effects in order to individualize drug treatment. Because unpredictable efficacy and high levels of...
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