Article
Pharmacogenomics: a tool for improving cancer chemotherapy.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Oct 2008
Monzó Mariano, Navarro Alfons, Ferrer Gerardo, Artells Rosa
Abstract excerpt
When an anticancer drug is captured and transported to the interior of a cell, many biochemical processes intervene in the metabolism of the drug. First, the Phase I and Phase II enzymes produce metabolites, which are then excreted via the ABC-transporter enzymes. Finally, the remaining drug binds to its molecular target. Genetic alterations known as polymorphisms in any of the proteins that intervene in these...
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