Article
Pharmacogenetics and cancer therapy.
Nature reviews. Cancer - 1 Nov 2001
Relling M V, Dervieux T
Abstract excerpt
Pharmacogenetics is the study of how genetic variations affect drug response. These variations can affect a patient's response to cancer drugs, for which there is usually a fine line between a dosage that has a therapeutic effect and one that produces toxicity. Gaining better insight into the genetic elements of both the patient and the tumour that affect drug efficacy will eventually allow for individualized...
Topics
- ATP-Binding Cassette Transporters
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Biotransformation
- Cytochrome P-450 Enzyme System
- Enzyme Inhibitors
- Folic Acid Antagonists
- Forecasting
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype