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Article

Association of Polymorphisms in T-Cell Activation Costimulatory/Inhibitory Signal Genes With Allograft Kidney Rejection Risk.

Frontiers in immunology - 1 Jan 2021

Santiago Jose Luis, Sánchez-Pérez Luis, Pérez-Flores Isabel, de la Higuera Maria Angeles Moreno, Romero Natividad Calvo, Querol-García Javier, Urcelay Elena, Sánchez-Fructuoso Ana Isabel

Abstract excerpt

The genes CD28, CD86 and CTLA-4 conform the costimulatory (CD28-CD86) or inhibitory (CTLA-4-CD86) signal in T-cell activation. T-cell immune response has a critical role in allograft rejection, and single nucleotide polymorphisms (SNPs) located in these genes have been widely analyzed with controversial results. We analyzed a group of SNPs located in the three genes: CD28: rs3116496; CD86: rs1129055; and CTLA-4:...

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Identifiers

PMID: 34149691
DOI: 10.3389/fimmu.2021.650979
PMCID: PMC8206554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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