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Article

HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development.

Development (Cambridge, England) - 1 Nov 2005

Norton William H J, Ledin Johan, Grandel Heiner, Neumann Carl J

Abstract excerpt

Heparan sulphate proteoglycans (HSPGs) are known to be crucial for signalling by the secreted Wnt, Hedgehog, Bmp and Fgf proteins during invertebrate development. However, relatively little is known about their effect on developmental signalling in vertebrates. Here, we report the analysis of daedalus, a novel zebrafish pectoral fin mutant. Positional cloning identified fgf10 as the gene disrupted in daedalus. We...

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Identifiers

PMID: 16221725
DOI: 10.1242/dev.02084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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