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Article

Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans.

PLoS genetics - 1 Jan 2017

Blanchette Cassandra R, Thackeray Andrea, Perrat Paola N, Hekimi Siegfried, Bénard Claire Y

Abstract excerpt

The regulation of cell migration is essential to animal development and physiology. Heparan sulfate proteoglycans shape the interactions of morphogens and guidance cues with their respective receptors to elicit appropriate cellular responses. Heparan sulfate proteoglycans consist of a protein core with attached heparan sulfate glycosaminoglycan chains, which are synthesized by glycosyltransferases of the...

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PMID: 28068429
DOI: 10.1371/journal.pgen.1006525
PMCID: PMC5221758

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EXT1
EXT2

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Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans.PMID 28068429Read ↗

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