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Article

Heparan sulphate proteoglycans: the sweet side of development.

Nature reviews. Molecular cell biology - 1 Jul 2005

Häcker Udo, Nybakken Kent, Perrimon Norbert

Abstract excerpt

Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports...

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PMID: 16072037
DOI: 10.1038/nrm1681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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