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Article

Heterozygous mice with Ric-8 mutation exhibit impaired spatial memory and decreased anxiety.

Behavioural brain research - 15 Feb 2006

Tõnissoo Tambet, Kõks Sulev, Meier Riho, Raud Sirli, Plaas Mario, Vasar Eero, Karis Alar

Abstract excerpt

Ric-8 is a guanine nucleotide exchange factor for a subset of Galpha proteins and it is required to maintain Galpha(q) and the Galpha(s) pathways in functional state. In adult mice Ric-8 is expressed in regions involved in the regulation of behavior (neocortex, cingulate cortex and hippocampus). As Ric-8 is shown to regulate neuronal transmitter release, the aim of present study was to perform behavioral analysis...

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Identifiers

PMID: 16221497
DOI: 10.1016/j.bbr.2005.08.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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