Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death.

PloS one - 1 Jan 2013

Ruisu Katrin, Kask Keiu, Meier Riho, Saare Merly, Raid Raivo, Veraksitš Alar, Karis Alar, Tõnissoo Tambet, Pooga Margus

Abstract excerpt

Resistance to inhibitors of cholinesterase 8 (RIC8) is a guanine nucleotide exchange factor required for the intracellular regulation of G protein signalling. RIC8 activates different Gα subunits via non-canonical pathway, thereby amplifying and prolonging the G protein mediated signal. In order to circumvent the embryonic lethality associated with the absence of RIC8A and to study its role in the nervous system,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Guanine Nucleotide Exchange Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Skeletal

Share to Muscular Atrophy

Share to Myocardium

Share to Neuromuscular Junction

Share to Organ Specificity

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 23977396
DOI: 10.1371/journal.pone.0074031
PMCID: PMC3745415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death.PMID 23977396Read ↗

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology.Semantic proximity Read ↗

Role of the Rho GTPase-activating protein RICS in neurite outgrowth.Semantic proximity Read ↗

Depletion of Ric-8B leads to reduced mTORC2 activitySemantic proximity Read ↗

RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system.Semantic proximity Read ↗

Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network.Semantic proximity Read ↗

Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death.Semantic proximity Read ↗

A genetic selection for Caenorhabditis elegans synaptic transmission mutants.Semantic proximity Read ↗

A mouse model of AChR deficiency syndrome with a phenotype reflecting the human condition.Semantic proximity Read ↗

Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice.Semantic proximity Read ↗

Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.Semantic proximity Read ↗

Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus.Semantic proximity Read ↗

Essential functions of synapsins I and II in synaptic vesicle regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.