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Article

Efficient expression of gene variants that harbour AGA codons next to the initiation codon.

Nucleic acids research - 1 Jan 2007

Zamora-Romo Efraín, Cruz-Vera Luis Rogelio, Vivanco-Domínguez Serafín, Magos-Castro Marco Antonio, Guarneros Gabriel

Abstract excerpt

In an effort to improve the knowledge about the rules which direct the effect of the early ORF sequences on translation efficiency, we have analyzed the effect of pairs of the six arginine codons at the second and third positions on the expression of lacZ variants. Whereas the pairs of identical AGA or AGG codons were favorable for the gene expression, identical pairs of each of the four CGN codons were very...

Topics

Arginine
Carboxylic Ester Hydrolases
Codon
Codon, Initiator
Escherichia coli
Gene Expression Regulation, Bacterial
Genes, Reporter
Genetic Variation
Mutation
Protein Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

RNA, Transfer, Amino Acyl

beta-Galactosidase

Source

Open in PubMed Open full text

Identifiers

PMID: 17726048
DOI: 10.1093/nar/gkm643
PMCID: PMC2034473

Genes

AGA
CGN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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