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Article

Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli.

Current opinion in biotechnology - 1 Oct 1995

Kane J F

Abstract excerpt

Within Escherichia coli and other species, a clear codon bias exists among the 61 amino acid codons found within the population of mRNA molecules, and the level of cognate tRNA appears directly proportional to the frequency of codon usage. Given this situation, one would predict translational problems with an abundant mRNA species containing an excess of rare low tRNA codons. Such a situation might arise after...

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Identifiers

PMID: 7579660
DOI: 10.1016/0958-1669(95)80082-4

Genes

AGA
CGA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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