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Article

Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli.

Current opinion in biotechnology - 1 Oct 1995

Kane J F

Abstract excerpt

Within Escherichia coli and other species, a clear codon bias exists among the 61 amino acid codons found within the population of mRNA molecules, and the level of cognate tRNA appears directly proportional to the frequency of codon usage. Given this situation, one would predict translational pro...

Topics

Arginine
Base Sequence
Codon
Escherichia coli
Gene Expression
Molecular Sequence Data
Multigene Family
Mutation
Protein Biosynthesis
Recombinant Proteins
Ribosomes

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Source

Identifiers

PMID: 7579660
DOI: 10.1016/0958-1669(95)80082-4

Genes

AGA
CGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7579660-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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