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Genotypic analysis of the protease and reverse transcriptase of HIV type 1 subtype C isolates from antiretroviral drug-naive adults in Malawi.

AIDS research and human retroviruses - 1 Sept 2005

Petch L A, Hoffman I F, Jere C S, Kazembe P N, Martinson F E, Chilongozi D, Fiscus S A, Cohen M S

Abstract excerpt

The protease (PR) and reverse transcriptase (RT) regions of HIV-1 isolates from 21 antiretroviral (ARV)-naive Malawian adults were sequenced and analyzed to determine the prevalence of drug resistance-associated mutations in this population. Phylogenetic analysis confirmed that all isolates grouped with HIV-1 subtype C, the predominant subtype in Malawi. No major mutations associated with resistance to PR...

Topics

Adult
Amino Acid Sequence
Consensus Sequence
Drug Resistance, Viral
HIV Infections
HIV Protease
HIV Reverse Transcriptase
HIV-1
Humans
Malawi
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phylogeny

Sequence Alignment

Source

Identifiers

PMID: 16218804
DOI: 10.1089/aid.2005.21.799

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