Article
Protease mutations in HIV-1 non-B strains infecting drug-naive villagers in Cameroon.
AIDS research and human retroviruses - 1 Jan 2004
Konings Frank A J, Zhong Ping, Agwara Moise, Agyingi Lucy, Zekeng Leopold, Achkar Jacqueline M, Ewane Leonard, Saa, Afane Ze Emmanuel, Kinge Thompson, Nyambi Phillipe N
Abstract excerpt
To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the...
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