Article
The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy.
AIDS (London, England) - 1 Jun 2009
Hosseinipour Mina C, van Oosterhout Joep J G, Weigel Ralf, Phiri Sam, Kamwendo Debbie, Parkin Neil, Fiscus Susan A, Nelson Julie A E, Eron Joseph J, Kumwenda Johnstone
Abstract excerpt
BACKGROUND: Over 150,000 Malawians have started antiretroviral therapy (ART), in which first-line therapy is stavudine/lamivudine/nevirapine. We evaluated drug resistance patterns among patients failing first-line ART on the basis of clinical or immunological criteria in Lilongwe and Blantyre, Malawi. METHODS: Patients meeting the definition of ART failure (new or progressive stage 4 condition, CD4 cell count...
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