Article
Genetic variability of HIV-1 protease from Nigeria and correlation with protease inhibitors drug resistance.
Virus genes - 1 Mar 2001
Vicente A C, Agwale S M, Otsuki K, Njouku O M, Jelpe D, Idoko J A, Caride E, Brindeiro R M, Tanuri A
Abstract excerpt
In Nigeria, the most populous country in Africa, the characterization of HIV-1 strains has been limited. In this study we evaluated the genetic diversity of the protease coding region, one of the anti-retroviral therapy target, and investigated the presence of mutations related to resistance to HIV protease inhibitors. We analyzed samples collected during 1996 and all patients were anti-retroviral drug naïves....
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