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Article

Accumulation of infectious mutants in stocks during the propagation of fiber-modified recombinant adenoviruses.

Biochemical and biophysical research communications - 25 Nov 2005

Ugai Hideyo, Inabe Kumiko, Yamasaki Takahito, Murata Takehide, Obata Yuichi, Hamada Hirofumi, Yokoyama Kazunari K

Abstract excerpt

In infected cells, replication errors during viral proliferation generate mutations in adenoviruses (Ads), and the mutant Ads proliferate and evolve in the intracellular environment. Genetically fiber-modified recombinant Ads (rAd variants) were generated, by modification of the fiber gene, for therapeutic applications in host cells that lack or express reduced levels of the Coxsackievirus and adenovirus...

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Identifiers

PMID: 16214112
DOI: 10.1016/j.bbrc.2005.09.112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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