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Article

An alternative to the adenovirus inverted terminal repeat sequence increases the viral genome replication rate and provides a selective advantage in vitro.

The Journal of general virology - 1 Jul 2014

Wunderlich Kerstin, van der Helm Esmeralda, Spek Dirk, Vermeulen Mark, Gecgel Adile, Pau Maria Grazia, Vellinga Jort, Custers Jerome

Abstract excerpt

During the development of human adenovirus 35-derived replication-incompetent (rAd35) vaccine vectors for prevention of infectious diseases, we detected mutations in the terminal 8 nt of the inverted terminal repeats (ITRs) of rAd35. The switch from the plasmid-encoded sequence 5'-CATCATCA-3' to the alternative sequence 5'-CTATCTAT-3' in the ITRs was found to be a general in vitro propagation phenomenon, as shown...

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Identifiers

PMID: 24764357
DOI: 10.1099/vir.0.064840-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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