Article
Mutant presenilin 2 increased oxidative stress and p53 expression in neuronal cells.
Biochemical and biophysical research communications - 25 May 2007
Nguyen Hong Nga, Lee Moon Soon, Hwang Dae Youn, Kim Young Kyu, Yoon Do Young, Lee Jae Woong, Yun Yeo Pyo, Lee Myung Koo, Oh Ki Wan, Hong Jin Tae
Abstract excerpt
The learning and memory impairment of presenilin 2 transgenic mice was mentioned previously. In this study, exposing the presenilin 2 transfected PC12 cells to the 50 microM Abeta(25-35), 30 mM l-glutamate and 50 microM H(2)O(2) resulted in significant increase 8-oxodG and p53 levels of the cells expressing the mutant gene. The increase was also found in the mutant presenilin 2 transgenic mice brains...
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