Article
N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression.
Life sciences - 21 Apr 2002
Mori Masaki, Nakagami Hironori, Morishita Ryuichi, Mitsuda Noriaki, Yamamoto Kei, Yoshimura Shin-ichi, Ohkubo Nobutaka, Sato Naoyuki, Ogihara Toshio, Kaneda Yasufumi
Abstract excerpt
A missense mutation (N1411) in Presenilin-2 (PS-2) gene is associated with early-onset familial Alzheimer's disease. In this study, SK-N-SH human neuroblastoma cells were transfected with wild-type and mutant PS-2 gene to examine presenilin-2 effects on apoptosis. Serum deprivation resulted in enhanced apoptosis in mutant PS-2 comparing with wild-type PS-2. Similarly, mutant PS-2 induced lactate dehydrogenase...
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