Article
Mutant presenilin 2 causes abnormality in the brain lipid profile in the development of Alzheimer's disease.
Archives of pharmacal research - 1 Oct 2006
Nguyen Hong Nga, Son Dong Ju, Lee Jae Woong, Hwang Dae Youn, Kim Young Kyu, Cho Jeong Sik, Lee Ung Soo, Yoo Hwan Soo, Moon Dong Cheul, Oh Ki Wan, Hong Jin Tae
Abstract excerpt
Mutation in the presenilin 2 (PS2mt) is known to be one of factors involved in the development of Alzheimer's disease (AD). It was recently revealed that an abnormality of lipid metabolism is a phenomenon occurring in AD. Therefore, the aim of this study was to investigate the potential relationship between the mutation of PS2 and alterations of the lipid profile within the brain. The results showed there...
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