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Article

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation.

Science (New York, N.Y.) - 6 Dec 1996

Wolozin B, Iwasaki K, Vito P, Ganjei J K, Lacanà E, Sunderland T, Zhao B, Kusiak J W, Wasco W, D'Adamio L

Abstract excerpt

Overexpression of the familial Alzheimer's disease gene Presenilin 2 (PS2) in nerve growth factor-differentiated PC12 cells increased apoptosis induced by trophic factor withdrawal or beta-amyloid. Transfection of antisense PS2 conferred protection against apoptosis induced by trophic withdrawal in nerve growth factor-differentiated or amyloid precursor protein-expressing PC12 cells. The apoptotic cell death...

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Identifiers

PMID: 8939861
DOI: 10.1126/science.274.5293.1710

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Related research

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Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation.PMID 8939861Read ↗

Overexpression of wild-type presenilin 2 or its familial Alzheimer's disease-associated mutant does not induce or increase susceptibility to apoptosis in different cell lines.Semantic proximity Read ↗

Pro‐apoptotic effect of presenilin 2 (PS2) overexpression is associated with down‐regulation of Bcl‐2 in cultured neuronsSemantic proximity Read ↗

N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression.Semantic proximity Read ↗

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Semantic proximity Read ↗

Regulation of apoptosis by presenilin 1.Semantic proximity Read ↗

Recent insights on the pro-apoptotic phenotype elicited by presenilin 2 and its caspase and presenilinase-derived fragments.Semantic proximity Read ↗

The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart.Semantic proximity Read ↗

Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.Semantic proximity Read ↗

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.Semantic proximity Read ↗

Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant.Semantic proximity Read ↗

Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster.Semantic proximity Read ↗

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.Semantic proximity Read ↗

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