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Article

Associations of the IL12B promoter polymorphism in longitudinal data from asthmatic patients 7 to 42 years of age.

The Journal of allergy and clinical immunology - 1 Mar 2004

Khoo Siew-Kim, Hayden Catherine M, Roberts Mary, Horak Elisabeth, de Klerk Nick, Zhang Guicheng, Robertson Colin F, Goldblatt Jack, Le Souëf Peter

Abstract excerpt

BACKGROUND: The IL12B gene encodes the p40 chain of IL-12, a proinflammatory cytokine that antagonizes TH2 expression and hence may play a critical role in the pathogenesis of airway inflammation observed in asthma. A promoter polymorphism of the gene was recently shown to be associated with asthma severity in children but only in heterozygotes. OBJECTIVE: The aim of the present study was to test the hypothesis...

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Source

Identifiers

PMID: 15007350
DOI: 10.1016/j.jaci.2003.10.043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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