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Article

Cyclin D1 G870A Polymorphism: Relation to the Risk of ALL Development, Prognosis Impact, and Methotrexate Cytotoxicity.

Asian Pacific journal of cancer prevention : APJCP - 1 Oct 2020

El Menshawy Nadia, El Marghany Ahmed B, Sarhan Mohamed M, Aladle Doaa A

Abstract excerpt

BACKGROUND: Cyclin D1 (CCND1) regulates cell cycle progression during the late G1 and S phase and takes part in methotrexate metabolism. It was hypothesized that CCND1 gene polymorphism affects acute lymphoblastic leukemia (ALL) development, prognosis and may relate to methotrexate cytotoxicity. SUBJECTS AND METHODS: This study included 50 ALL patients and 50 healthy controls, CCND1 G870A polymorphism was studied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33112552
DOI: 10.31557/APJCP.2020.21.10.2941
PMCID: PMC7798150

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