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Article

Association between the polymorphism rs3217927 of CCND2 and the risk of childhood acute lymphoblastic leukemia in a Chinese population.

PloS one - 1 Jan 2014

Zhang Heng, Zhou Yan, Rui Yaoyao, Wang Yaping, Li Jie, Rong Liuchen, Wang Meilin, Tong Na, Zhang Zhengdong, Chen Jing, Fang Yongjun

Abstract excerpt

CyclinD proteins, the ultimate recipients of mitogenic and oncogenic signals, play a crucial role in cell-cycle regulation. CyclinD2, one of the cyclinD family, is overexpressed in T-acute lymphoblastic leukemia (ALL) and B-cell chronic lymphocytic leukemia and involved in the pathogenesis of leukemias. Recent reports indicated that CCND2 polymorphisms are associated with human cancer risk, thusly we hypothesized...

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Identifiers

PMID: 24743557
DOI: 10.1371/journal.pone.0095059
PMCID: PMC3990598

Genes

CCND2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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