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Article

Disruption of the p53-p53r2 DNA repair system in ulcerative colitis contributes to colon tumorigenesis.

International journal of cancer - 15 Mar 2006

Yoshida Tsutomu, Haga Shiori, Numata Yoshiko, Yamashita Kazuya, Mikami Tetuo, Ogawa Taishi, Ohkusa Toshifumi, Okayasu Isao

Abstract excerpt

With ulcerative colitis (UC)-associated tumorigenesis, p53 gene alteration is considered to be a key event. To clarify whether the p53-checkpoint is operating in foci of inflammation and that its disruption is a feature of UC-associated neoplasms, the present immunohistochemical study was conducted. Since accumulation of butyric acid with active UC is associated with apoptosis, effects of in vitro exposure of...

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Identifiers

PMID: 16206288
DOI: 10.1002/ijc.21538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the p53-p53r2 DNA repair system in ulcerative colitis contributes to colon tumorigenesis.PMID 16206288Read ↗

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