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Article

Polyamine biosynthesis in relation to K-ras and p-53 mutations in colorectal carcinoma.

Scandinavian journal of gastroenterology - 1 May 2004

Linsalata M, Notarnicola M, Caruso M G, Di Leo A, Guerra V, Russo F

Abstract excerpt

BACKGROUND: Polyamines are important polycations found in high concentrations in gastrointestinal neoplasms, and ornithine decarboxylase is the key enzyme in their biosynthesis. Also genes with oncogenic potential (e.g. K-ras and p53) contribute to neoplastic transformation by modifying normal cellular proliferation and differentiation. Our aim was to evaluate the ornithine decarboxylase activity and polyamine...

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Source

Identifiers

PMID: 15180186
DOI: 10.1080/0036552031008755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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