Absence of mutations in the functional parts of the p120-GAP gene in carcinogen-induced mouse liver tumors.

doi:10.1093/carcin/13.10.1903

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Article

Absence of mutations in the functional parts of the p120-GAP gene in carcinogen-induced mouse liver tumors.

Carcinogenesis - 1 Oct 1992

Müller O, Kress S, Schwarz M

Abstract excerpt

The GTPase activating proteins (GAP) stimulate the intrinsic GTPase activity of ras-p21 thus converting the protein into its inactive form. We have now analyzed carcinogen-induced mouse liver tumors for the possible occurrence of mutational changes in one of the two known GAP genes, namely p120-G...

Topics

Animals
Base Sequence
Diethylnitrosamine
GTPase-Activating Proteins
Genes, ras
Liver Neoplasms, Experimental
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Molecular Sequence Data
Mutation
Proteins
Proto-Oncogene Proteins p21(ras)
ras GTPase-Activating Proteins

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