Absence of mutations in the functional parts of the p120-GAP gene in carcinogen-induced mouse liver tumors.

doi:10.1093/carcin/13.10.1903

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Absence of mutations in the functional parts of the p120-GAP gene in carcinogen-induced mouse liver tumors.

Carcinogenesis - 1 Oct 1992

Müller O, Kress S, Schwarz M

Abstract excerpt

The GTPase activating proteins (GAP) stimulate the intrinsic GTPase activity of ras-p21 thus converting the protein into its inactive form. We have now analyzed carcinogen-induced mouse liver tumors for the possible occurrence of mutational changes in one of the two known GAP genes, namely p120-GAP. RNA from a total of 21 tumors was reverse transcribed by use of GAP-specific primers, amplified by PCR and...

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Absence of mutations in the functional parts of the p120-GAP gene in carcinogen-induced mouse liver tumors.

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