Article

A study of the molecular pharmacological properties of C5a and C5a des Arg : defining their biased agonist profile and contrasting biological function

2017-01-01

Abstract excerpt

The complement system provides an essential role in the orchestration of an effective immune response against microbial infection. Activation leads to the generation of C5a which activates receptors expressed on immune cells promoting microbial clearance. Dysregulation of the complement system that results in the excessive production of C5a can lead to host tissue damage. This has fuelled drug discovery efforts to...

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Literature Corpus work: 9c74791d-c0f4-5f1a-ba90-fe92bf96dd6b
DOI: 10.17638/03016515

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