C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation.

doi:10.1016/j.molimm.2009.06.007

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Article

C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation.

Molecular immunology - 1 Sept 2009

Cui Wei, Simaan May, Laporte Stephane, Lodge Robert, Cianflone Katherine

Abstract excerpt

UNLABELLED: C5L2, a G-protein-coupled receptor (GPCR), has been identified as an ASP (C3adesArg) and C5a receptor. Controversy exists regarding both ligand binding and functionality. ASP activation of C5L2 is proposed to regulate fat storage. C5L2 is also proposed as a decoy receptor for C5a, an inflammatory mediator, based on absence of Ca(2+) or chemotaxis changes. AIMS: (i) to evaluate C5L2 receptor activation...

Topics

Acylation
Arrestins
Cell Line
Complement C3a
Complement C5a
Endocytosis
Humans
Mutation
Phosphorylation
Receptor, Anaphylatoxin C5a
Receptors, Chemokine
Recombinant Proteins
Serine
Transfection
beta-Arrestin 2
beta-Arrestins
rab GTP-Binding Proteins

Source

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Identifiers

PMID: 19615750
DOI: 10.1016/j.molimm.2009.06.007

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