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Article

Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction.

Gene - 21 Nov 2005

Park Jeehye, Kim Sung Yun, Cha Guang-Ho, Lee Sung Bae, Kim Sunhong, Chung Jongkyeong

Abstract excerpt

DJ-1 is linked to an early-onset autosomal recessive Parkinson's disease (PD) characterized primarily by selective loss of dopaminergic (DA) neurons, which results in motor disturbances. However, our understanding on how mutations in DJ-1 are related to PD is unclear. Here, we isolated the DJ-1 orthologue, DJ-1beta, in Drosophila and characterized its expression and loss-of-function mutants. We observed its...

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Source

Identifiers

PMID: 16203113
DOI: 10.1016/j.gene.2005.06.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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