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Article

p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.

Cell - 2 Jun 2006

Zohn Irene E, Li Yingqiu, Skolnik Edward Y, Anderson Kathryn V, Han Jiahuai, Niswander Lee

Abstract excerpt

During vertebrate gastrulation, an epithelial to mesenchymal transition (EMT) is necessary for migration of mesoderm from the primitive streak. We demonstrate that p38 MAP kinase and a p38-interacting protein (p38IP) are critically required for downregulation of E-cadherin during gastrulation. In an ENU-mutagenesis screen we identified the droopy eye (drey) mutation, which affects splicing of p38IP. p38IP(drey)...

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Identifiers

PMID: 16751104
DOI: 10.1016/j.cell.2006.03.048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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