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Detection of specific sequences in RNA using differential adsorption of single-stranded oligonucleotides on gold nanoparticles.

Analytical chemistry - 1 Oct 2005

Li Huixiang, Rothberg Lewis

Abstract excerpt

We have used the disparity in adsorption rates for single- and double-stranded RNA on ionically coated gold nanoparticles suspended in a colloid to design a rapid sequence identification assay. Unlabeled target RNA and a probe sequence are mixed prior to exposure to the gold nanoparticles to enable efficient hybridization. We have designed assays based on either color changes or fluorescence that are sensitive to...

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PMID: 16194083
DOI: 10.1021/ac050921y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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