Article
Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2006
Ikeda Masashi, Iwata Nakao, Kitajima Tsuyoshi, Suzuki Tatsuyo, Yamanouchi Yoshio, Kinoshita Yoko, Ozaki Norio
Abstract excerpt
Several lines of evidence suggest that abnormalities in the serotonin system may be related to the pathophysiology of schizophrenia. The 5-HT7 receptor is considered to be a possible schizophrenia-susceptibility factor, based on findings from binding, animal, postmortem, and genomewide linkage studies. In this study, we conducted linkage disequilibrium (LD) mapping of the human 5-HT7 receptor gene (HTR7) and...
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