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Article

5-HT1A receptor (HTR1A) 5' region haplotypes significantly affect protein expression in vitro.

Neuroscience letters - 18 Jan 2017

Wu Xue, Yao Jun, Ding Mei, Shi Zhang-Sen, Xu Feng-Ling, Zhang Jing-Jing, Wang Bao-Jie

Abstract excerpt

The aim of this study was to explore the role of two SNPs (rs6295 & rs113195492) in the HTR1A gene promoter region that regulates the expression of the 5-HT1A receptor. A fragment spanning from -551 to +672 of HTR1A (Transcription start site +1) was cloned into the pGL-3 Basic Vector and three haplotype plasmids composed of two SNPs were constructed. HEK-293 cells and the SK-N-SH cells were transfected with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27939355
DOI: 10.1016/j.neulet.2016.12.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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