Family-based association study of the 5-HT transporter gene and schizophrenia.

doi:10.1017/S1461145704004948

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Article

Family-based association study of the 5-HT transporter gene and schizophrenia.

The international journal of neuropsychopharmacology - 1 Mar 2005

Dubertret Caroline, Hanoun Naima, Adès Jean, Hamon Michel, Gorwood Philip

Abstract excerpt

The gene coding for the 5-HT transporter (5-HTT) is considered as a candidate gene for schizophrenia, because this transporter plays a key role in serotonin neurotransmission. Previous genetic studies focusing on this gene yielded conflicting results, presumably because of stratification biases linked to the case-control association study approach, and the potential genetic and phenotypic heterogeneity of...

Topics

Adult
Aged
Female
Genetic Carrier Screening
Genetic Predisposition to Disease
Genetic Variation
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Male
Membrane Glycoproteins
Membrane Transport Proteins
Middle Aged
Nerve Tissue Proteins

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Open in PubMed

Identifiers

PMID: 15638952
DOI: 10.1017/S1461145704004948

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Phenotype

Polymorphism, Genetic

Promoter Regions, Genetic