Article
Evolution of HIV-1 genotype in plasma RNA and peripheral blood mononuclear cells proviral DNA after interruption and resumption of antiretroviral therapy.
Antiviral therapy - 1 Jan 2012
Imaz Arkaitz, Olmo Montserrat, Peñaranda Maria, Gutiérrez Félix, Romeu Joan, Larrousse Maria, Domingo Pere, Oteo José A, Niubó Jordi, Curto Jordi, Vilallonga Concepción, Masiá Mar, López-Aldeguer José, Iribarren José A, Podzamczer Daniel
Abstract excerpt
BACKGROUND: Structured antiretroviral therapy interruption (TI) is discouraged because of poorer AIDS and non-AIDS-related outcomes, but is often inevitable in clinical practice. Certain strategies could reduce the emergence of resistance mutations related to TI. METHODS: A total of 106 HIV-1-infected patients on stable HAART with undetectable plasma viral load were randomized to therapy continuation (n=50) or...
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