Article
Tumor deletion mapping on chromosome 11q13 in eight families with isolated familial somatotropinoma and in 15 sporadic somatotropinomas.
The Journal of clinical endocrinology and metabolism - 1 Dec 2005
Soares Beatriz S, Eguchi Kuniki, Frohman Lawrence A
Abstract excerpt
CONTEXT: Isolated familial somatotropinoma (IFS) is a rare endocrine disease defined as the occurrence of at least two cases of acromegaly or gigantism in a family that does not exhibit features of Carney complex or multiple endocrine neoplasia type 1. Analysis of the multigenerational expression in families suggests that IFS is inherited as an autosomal dominant disease with incomplete penetrance. The...
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