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Article

KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas.

European journal of endocrinology - 1 Feb 2024

Chasseloup Fanny, Regazzo Daniela, Tosca Lucie, Proust Alexis, Kuhn Emmanuelle, Hage Mirella, Jublanc Christel, Mokhtari Karima, Dalle Nogare Mattia, Avallone Serena, Ceccato Filippo, Tachdjian Gerard, Salenave Sylvie, Young Jacques, Gaillard Stephan, Parker Fabrice, Boch Anne-Laure, Chanson Philippe, Bouligand Jerome, Occhi Gianluca, Kamenický Peter

Abstract excerpt

IMPORTANCE: A paradoxical increase of growth hormone (GH) following oral glucose load has been described in ∼30% of patients with acromegaly and has been related to the ectopic expression of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in somatotropinomas. Recently, we identified germline pathogenic variants and somatic loss of heterozygosity of lysine demethylase 1A (KDM1A) in patients...

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PMID: 38330165
DOI: 10.1093/ejendo/lvae013

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