Isolated Familial Somatotropinomas: Establishment of Linkage to Chromosome 11q13.1–11q13.3 and Evidence for a Potential Second Locus at Chromosome 2p16–12¹

Abstract excerpt

The majority of somatotropinomas are sporadic, although a small number occur with a familial aggregation, either as a component of an endocrine neoplasia complex that includes multiple endocrine neoplasia type 1 (MEN-1) and Carney complex (CNC) or as isolated familial somatotropinomas (IFS). IFS is defined as the occurrence of at least two cases of acromegaly or gigantism in a family that does not exhibit MEN-1...

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