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Article

Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.

The Journal of clinical investigation - 1 Jun 1993

Thakker R V, Pook M A, Wooding C, Boscaro M, Scanarini M, Clayton R N

Abstract excerpt

The molecular pathology of somatotrophinomas has been investigated by a combined search for dominant mutations of the gene encoding the Gs alpha protein and for recessive mutations involving chromosome 11q13, which contains the gene causing multiple endocrine neoplasia type 1 (MEN1). Somatotrophinomas and peripheral leukocytes were obtained from thirteen patients with acromegaly; one patient also suffered from...

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Source

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Identifiers

PMID: 8514889
DOI: 10.1172/JCI116524
PMCID: PMC443349

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.PMID 8514889Read ↗

Imprinting of the G(s)alpha gene GNAS1 in the pathogenesis of acromegaly.Semantic proximity Read ↗

11q13 allelic loss in pituitary tumors in patients with multiple endocrine neoplasia syndrome type 1.Semantic proximity Read ↗

Isolated familial somatotropinomas: clinical and genetic considerations.Semantic proximity Read ↗

Isolated Familial Somatotropinomas: Establishment of Linkage to Chromosome 11q13.1–11q13.3 and Evidence for a Potential Second Locus at Chromosome 2p16–12<sup>1</sup>Semantic proximity Read ↗

Tumor deletion mapping on chromosome 11q13 in eight families with isolated familial somatotropinoma and in 15 sporadic somatotropinomas.Semantic proximity Read ↗

Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.Semantic proximity Read ↗

Somatotroph Tumors and the Epigenetic Status of the GNAS Locus.Semantic proximity Read ↗

Molecular genetic studies of sporadic pituitary tumors.Semantic proximity Read ↗

Allele loss on chromosome 11 in a pituitary tumor from a patient with multiple endocrine neoplasia type 1.Semantic proximity Read ↗

Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas.Semantic proximity Read ↗

Somatotrophinomas in multiple endocrine neoplasia type 1: a review of clinical phenotype and insulin-like growth factor-1 levels in a large multiple endocrine neoplasia type 1 kindred.Semantic proximity Read ↗

Hypermethylator Phenotype and Ectopic GIP Receptor in GNAS Mutation-Negative SomatotropinomasSemantic proximity Read ↗

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