Article
Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.
The Journal of clinical investigation - 1 Jun 1993
Thakker R V, Pook M A, Wooding C, Boscaro M, Scanarini M, Clayton R N
Abstract excerpt
The molecular pathology of somatotrophinomas has been investigated by a combined search for dominant mutations of the gene encoding the Gs alpha protein and for recessive mutations involving chromosome 11q13, which contains the gene causing multiple endocrine neoplasia type 1 (MEN1). Somatotrophi...
Topics
- Acromegaly
- Adult
- Aged
- Alleles
- Base Sequence
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Female
- GTP-Binding Proteins
- Genes, Dominant
- Genes, Recessive
- Genes, Suppressor
- Growth Hormone
- Humans
- Male
- Middle Aged
- Molecular Sequence Data