Article
Genome-wide scan identifies novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma.
Endocrine-related cancer - 1 Sept 2009
Khoo S K, Pendek R, Nickolov R, Luccio-Camelo D C, Newton T L, Massie A, Petillo D, Menon J, Cameron D, Teh B T, Chan S-P
Abstract excerpt
Isolated familial somatotropinoma (IFS) accounts for 18% of familial isolated pituitary adenoma (FIPA) cases. Recently, germline mutations of the aryl hydrocarbon receptor-interacting protein gene (AIP) have been found in families with pituitary adenoma predisposition, FIPA, and IFS. In this study, we investigate the AIP mutation status and perform a genome-wide scan to search for the modifier regions of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.